Reactome: A Curated Pathway Database

ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)

Stable Identifier
R-HSA-2022399
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ENPEP Hydrolyzes Angiotensin II to Yield Angiotensin III
Locations in the PathwayBrowser
Summation

Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallopeptidase activity of ENPEP Dimer [plasma membrane] ENPEP Dimer [plasma membrane] metallopeptidase activity (0008237)
Orthologous Events