Reactome: A Curated Pathway Database

ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (R-HSA-2022399)

Species Homo sapiens


Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ENPEP Dimer metallopeptidase activity (0008237)
Literature References
pubMedId Title Journal Year
16790432 Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV J Biol Chem 2006