Reactome: A Curated Pathway Database

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (R-HSA-2022403) [Homo sapiens]


Renin bound to the (pro)renin receptor (ATP6AP2) hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Binding to the (pro)renin receptor increases the catalytic efficiency of renin 4-fold (Nguyen et al. 2002). Aliskiren, a drug used clinically to treat hypertension, inhibits cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Renin:Prorenin Receptor aspartic-type endopeptidase activity (0004190)
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Regulation type Name
Literature References
pubMedId Title Journal Year
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 2002
22193701 Aliskiren displays long-lasting interactions with human renin Naunyn Schmiedebergs Arch Pharmacol 2011
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor Biochem Biophys Res Commun 2003