Reactome: A Curated Pathway Database

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (R-HSA-2022403)

Species Homo sapiens


Renin bound to the (pro)renin receptor (ATP6AP2) hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Binding to the (pro)renin receptor increases the catalytic efficiency of renin 4-fold (Nguyen et al. 2002). Aliskiren, a drug used clinically to treat hypertension, inhibits cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

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Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
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Input entries
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Catalyst Activity
PhysicalEntity Activity Active Units
Renin:Prorenin Receptor aspartic-type endopeptidase activity (0004190)
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Regulation type Name
Literature References
pubMedId Title Journal Year
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 2002
22193701 Aliskiren displays long-lasting interactions with human renin Naunyn Schmiedebergs Arch Pharmacol 2011
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor Biochem Biophys Res Commun 2003