Reactome: A Curated Pathway Database

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
R-HSA-2022403
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Renin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
Locations in the PathwayBrowser
Summation

Renin bound to the (pro)renin receptor (ATP6AP2) hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Binding to the (pro)renin receptor increases the catalytic efficiency of renin 4-fold (Nguyen et al. 2002). Aliskiren, a drug used clinically to treat hypertension, inhibits cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of Renin:Prorenin Receptor [plasma membrane] Renin:Prorenin Receptor [plasma membrane] aspartic-type endopeptidase activity (0004190)
Orthologous Events