Reactome: A Curated Pathway Database

ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (R-HSA-2022405)

Species Homo sapiens

Summation

Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Ehlers and Kirsch 1988). ACE is found at the plasma membrane of endothelial cells. This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ACE(30-1306) metallodipeptidase activity (0070573)
This entry is regulated by
Regulation type Name
NegativeRegulation
PositiveRegulation