Reactome: A Curated Pathway Database
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ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2022405
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
Locations in the PathwayBrowser
Summation

Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Ehlers and Kirsch 1988). ACE is found at the plasma membrane of endothelial cells. This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallodipeptidase activity of ACE(30-1306) [plasma membrane] ACE(30-1306) [plasma membrane] metallodipeptidase activity (0070573)
Orthologous Events