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ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2022405
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
Locations in the PathwayBrowser
Summation

Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Ehlers and Kirsch 1988). ACE is found at the plasma membrane of endothelial cells. This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999).

Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
metallodipeptidase activity of ACE(30-1306) [plasma membrane]
Physical Entity
Activity
This entity is regulated by
Orthologous Events