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Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (R-HSA-2022411) [Homo sapiens]

Reaction
Summation

Cathepsin G hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Reilly et al. 1982, Owen and Campbell 1998, Raymond et al. 2010). Cathepsin bound to the plasma membrane of neutrophils has a higher activity than does soluble cathepsin G (Owen and Campbell 1998).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Cathepsin G serine-type endopeptidase activity (0004252)  
Literature References
pubMedId Title Journal Year
20889553 How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution J Immunol 2010
6807977 Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases J Biol Chem 1982
9570564 Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition J Immunol 1998
Inferred Entries
Orthologous events
 
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