Reactome: A Curated Pathway Database

Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (R-HSA-2022412)

Species Homo sapiens


Renin in the bloodstream hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I). Renin is produced in the juxtaglomerular cells of the kidney in response to reduced blood pressure. Aliskiren, a drug used clinically to treat hypertension, inhibits this reaction (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

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Additional Information
Compartment extracellular region
GO Biological Process angiotensin maturation (0002003)
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Catalyst Activity
PhysicalEntity Activity Active Units
Renin aspartic-type endopeptidase activity (0004190)
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Regulation type Name