Reactome: A Curated Pathway Database

Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (R-HSA-2022412) [Homo sapiens]


Renin in the bloodstream hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I). Renin is produced in the juxtaglomerular cells of the kidney in response to reduced blood pressure. Aliskiren, a drug used clinically to treat hypertension, inhibits this reaction (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Additional Information
Compartment extracellular region
GO Biological Process angiotensin maturation (0002003)
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Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Renin aspartic-type endopeptidase activity (0004190)  
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Regulation type Name