Reactome: A Curated Pathway Database

Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
R-HSA-2022412
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Renin Hydrolyzes Angiotensinogen to Yield Angiotensin I
Locations in the PathwayBrowser
Summation

Renin in the bloodstream hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I). Renin is produced in the juxtaglomerular cells of the kidney in response to reduced blood pressure. Aliskiren, a drug used clinically to treat hypertension, inhibits this reaction (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of Renin [extracellular region] Renin [extracellular region] aspartic-type endopeptidase activity (0004190)
Orthologous Events