Reactome: A Curated Pathway Database
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Phosphorylation of PLC-gamma1

Stable Identifier
R-HSA-202248
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of ZAP-70 and ITK tyrosine kinases [plasma membrane] ZAP-70 and ITK tyrosine kinases [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events