Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.
|ZAP-70 and ITK tyrosine kinases||protein tyrosine kinase activity (0004713)|
|11048639||The mechanism of phospholipase C-gamma1 regulation||Exp Mol Med||2000|