Reactome: A Curated Pathway Database

Phosphorylation of PLC-gamma1 (R-HSA-202248)

Species Homo sapiens


Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
11048639 The mechanism of phospholipase C-gamma1 regulation Exp Mol Med 2000