Reactome: A Curated Pathway Database

Keratan sulfate degradation (R-HSA-2022857)

Species Homo sapiens


Keratan sulfate proteoglycans (KSPGs) are degraded in lysosomes as part of normal homeostasis of glycoproteins. Glycoproteins must be completely degraded to avoid undigested fragments building up and causing a variety of lysosomal storage diseases. KSPGs are Asn-linked glycoproteins and are acted upon by exo-glycosidases to release sugar monomers. The main steps of degradation are shown representing the types of cleavage reactions that occur so the full degradation of KS is not shown to avoid repetition. The proteolysis of the core protein of the glycoprotein is not shown here (Winchester 2005, Aronson & Kuranda 1989).

Locations in the PathwayBrowser
Additional Information
GO Biological Process keratan sulfate catabolic process (0042340)
Literature References
pubMedId Title Journal Year
15647514 Lysosomal metabolism of glycoproteins Glycobiology 2005
2531691 Lysosomal degradation of Asn-linked glycoproteins FASEB J 1989