Reactome: A Curated Pathway Database

Chondroitin sulfate biosynthesis (R-HSA-2022870) [Homo sapiens]


Chondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002).

Additional Information
GO Biological Process chondroitin sulfate biosynthetic process (0030206)
Literature References
pubMedId Title Journal Year
17239764 Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches Adv Pharmacol 2006
12512856 Biosynthesis of chondroitin/dermatan sulfate IUBMB Life 2002