Reactome: A Curated Pathway Database
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Activation of Lck

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events