Reactome: A Curated Pathway Database

Activation of Lck (R-HSA-202291) [Homo sapiens]


The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.

Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
15489916 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation Oncogene 2004