Reactome: A Curated Pathway Database

Activation of Lck (R-HSA-202291)

Species Homo sapiens


The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
15489916 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation Oncogene 2004