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Dermatan sulfate biosynthesis

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Dermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues can be sulfated in CS chains but also the uronic acid
residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002).

Literature References
PubMed ID Title Journal Year
12512856 Biosynthesis of chondroitin/dermatan sulfate IUBMB Life 2002
Participant Of
Event Information
Orthologous Events