Reactome: A Curated Pathway Database

Dermatan sulfate biosynthesis

Stable Identifier
R-HSA-2022923
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Dermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues can be sulfated in CS chains but also the uronic acid
residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002).

Literature References
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Orthologous Events