Reactome: A Curated Pathway Database

HS-GAG biosynthesis (R-HSA-2022928) [Homo sapiens]


Heparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) consist of the disaccharide unit GlcNAc-GlcA (N-acetylglucosamine-glucuronic acid) connected by a beta1,4 linkage. Heparin is exclusively made in mast cells whereas HS is made by virtually every type of cell in the body. As the chain length increases, the polysaccharides can undergo modifcations such as epimerisation of glucuronic acid to iduronic acid and deacetylation and sulfation of GlcNAc to form sulfated glucosamine (Stringer & Gallagher 1997, Sasisekharan & Venkataraman 2000).

Additional Information
GO Biological Process glycosaminoglycan biosynthetic process (0006024)
Literature References
pubMedId Title Journal Year
9251237 Heparan sulphate Int J Biochem Cell Biol 1997
11102866 Heparin and heparan sulfate: biosynthesis, structure and function Curr Opin Chem Biol 2000