Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of heparan sulfate/heparin. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.
|GO Biological Process||glycosaminoglycan catabolic process (0006027)|
|15647514||Lysosomal metabolism of glycoproteins||Glycobiology||2005|