Reactome: A Curated Pathway Database

HS-GAG degradation

Stable Identifier
R-HSA-2024096
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of heparan sulfate/heparin. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.

Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins Glycobiology 2005
Participants
Participant Of
Orthologous Events