Reactome: A Curated Pathway Database

HS-GAG degradation (R-HSA-2024096) [Homo sapiens]


Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of heparan sulfate/heparin. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.

Additional Information
GO Biological Process glycosaminoglycan catabolic process (0006027)
Literature References
pubMedId Title Journal Year
15647514 Lysosomal metabolism of glycoproteins Glycobiology 2005