Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.
|Active PKC theta bound to DAG||protein serine/threonine kinase activity (0004674)|
|17468049||Post-translational modifications regulate distinct functions of CARMA1 and BCL10||Trends Immunol||2007|
|16356853||Phosphorylation of CARMA1: the link(er) to NF-kappaB activation||Immunity||2005|