Reactome: A Curated Pathway Database

Phosphorylation of CARMA1 (R-HSA-202437) [Homo sapiens]


Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Active PKC theta bound to DAG protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10 Trends Immunol 2007
16356853 Phosphorylation of CARMA1: the link(er) to NF-kappaB activation Immunity 2005