Reactome: A Curated Pathway Database

Phosphorylation of CARMA1

Stable Identifier
R-HSA-202437
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Active PKC theta bound to DAG [plasma membrane] Active PKC theta bound to DAG [plasma membrane] protein serine/threonine kinase activity (0004674)
Orthologous Events