Reactome: A Curated Pathway Database

Oligomerization of CARMA1 (R-HSA-202443)

Species Homo sapiens

Summation

After the phosphorylation and activation CARMA1 undergoes oligomerization, likely through its CC domain. CARMA1 is thought to oligomerize first as a trimer which triggers downstream oligomerization cascade that is ultimately necessary for the subsequent activation of the IKK complex.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol
Literature References
pubMedId Title Journal Year
15541657 The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling Semin Immunol 2004