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Oligomerization of CARMA1

Stable Identifier
R-HSA-202443
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After the phosphorylation and activation CARMA1 undergoes oligomerization, likely through its CC domain. CARMA1 is thought to oligomerize first as a trimer which triggers downstream oligomerization cascade that is ultimately necessary for the subsequent activation of the IKK complex.

Literature References
PubMed ID Title Journal Year
15541657 The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling Semin Immunol 2004
Participants
Participant Of
Orthologous Events