Phosphorylation of Bcl10

Stable Identifier
R-HSA-202459
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.
Literature References
PubMed ID Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Weil, R, Thome, M

Trends Immunol 2007
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of RIPK2 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!