Reactome: A Curated Pathway Database

Phosphorylation of Bcl10 (R-HSA-202459) [Homo sapiens]


Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
RIPK2 protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10 Trends Immunol 2007