Reactome: A Curated Pathway Database

Interaction of Bcl10 to CARMA1 (R-HSA-202466) [Homo sapiens]


Bcl10 is recruited to activated, oligomeric CARMA1 through a CARD-CARD interaction. Bcl10 is characterized by an N-terminal CARD motif and a C-terminal extension of ~130 amino acids rich in serine and threonine residues that serve as targets for multiple phosphorylation events.

Additional Information
Compartment cytosol , plasma membrane
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Literature References
pubMedId Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10 Trends Immunol 2007
15122200 CARMA1, BCL-10 and MALT1 in lymphocyte development and activation Nat Rev Immunol 2004