Reactome: A Curated Pathway Database

Translocation of TRAF6 to CBM complex (R-HSA-202472)

Species Homo sapiens

Summation

TRAF6, which plays central role in innate immune responses, is implicated as proximal downstream effector of MALT1. TRAF6 is a member of the TRAF proteins. It contains an N-term RING domain, followed by several Zn finger domains and C-term MATH domain. The MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization and thereby activate the ubiquitin ligase activity of TRAF6 to polyubiquitinate itself and NEMO.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes Mol Cell 2004