Reactome: A Curated Pathway Database

Translocation of TRAF6 to CBM complex

Stable Identifier
R-HSA-202472
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRAF6, which plays central role in innate immune responses, is implicated as proximal downstream effector of MALT1. TRAF6 is a member of the TRAF proteins. It contains an N-term RING domain, followed by several Zn finger domains and C-term MATH domain. The MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization and thereby activate the ubiquitin ligase activity of TRAF6 to polyubiquitinate itself and NEMO.

Literature References
Participants
Participant Of
Orthologous Events