Reactome: A Curated Pathway Database

Activation of TAK1-TAB2 complex

Stable Identifier
R-HSA-202510
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of TAB2/TAK1 complex [cytosol] TAB2/TAK1 complex [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events