Reactome: A Curated Pathway Database

Activation of TAK1-TAB2 complex (R-HSA-202510)

Species Homo sapiens


Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
TAB2/TAK1 complex protein serine/threonine kinase activity (0004674)