During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Studies of different NF-kB signaling pathways revealed several potential ubiquitination sites on NEMO (e.g., K285, K277, K309 and K399) (Fuminori et al. 2009).
|Ub-TRAF6 trimer bound to CBM complex||ubiquitin-protein transferase activity (0004842)|
|17728323||Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti||Hum Mol Genet||2007|
|17047224||Regulation and function of IKK and IKK-related kinases||Sci STKE||2006|