Reactome: A Curated Pathway Database

Branching and elongation of mother and daughter filaments

Stable Identifier
R-HSA-2029473
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments and the polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).

Literature References
Participants
Participant Of
Orthologous Events