Reactome: A Curated Pathway Database

Regulation of actin dynamics for phagocytic cup formation (R-HSA-2029482)

Species Homo sapiens

Summation

The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol , extracellular region
Literature References
pubMedId Title Journal Year
15452139 Regulation of WASP/WAVE proteins: making a long story short J Cell Biol 2004
17477841 Regulation of actin filament assembly by Arp2/3 complex and formins Annu Rev Biophys Biomol Struct 2007
15981459 Regulation of phagocytosis by Rho GTPases Curr Top Microbiol Immunol 2005