Reactome: A Curated Pathway Database

WWTR1 binds SMAD2/3:SMAD4 heterotrimer (R-HSA-2031355) [Homo sapiens]


In the cytosol of human embryonic stem cells, WWTR1 (TAZ) binds heterotrimer composed of two R-SMADs (SMAD2 and/or SMAD3) and SMAD4. This interaction involves the C-terminus of WWTR1 (TAZ) and the MH1 domain of SMAD proteins.

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Nat Cell Biol 2008