YAP1- and WWTR1 (TAZ)-stimulated gene expression

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R-HSA-2032785
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Pathway
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Homo sapiens
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5/5
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YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).
Literature References
PubMed ID Title Journal Year
16332960 A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

Murakami, M, Olson, EN, Nakagawa, O, Nakagawa, M

Proc Natl Acad Sci U S A 2005
20452772 Yorkie: the final destination of Hippo signaling

Oh, H, Irvine, KD

Trends Cell Biol 2010
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