Reactome: A Curated Pathway Database

YAP1- and WWTR1 (TAZ)-stimulated gene expression (R-HSA-2032785)

Species Homo sapiens

Summation

YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , nucleoplasm
GO Biological Process transcription initiation from RNA polymerase II promoter (0006367)
Literature References
pubMedId Title Journal Year
16332960 A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome Proc Natl Acad Sci U S A 2005
20452772 Yorkie: the final destination of Hippo signaling Trends Cell Biol 2010