Reactome: A Curated Pathway Database

YAP1- and WWTR1 (TAZ)-stimulated gene expression

Stable Identifier
R-HSA-2032785
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).

Literature References
Participants
Participant Of
Orthologous Events