Reactome: A Curated Pathway Database

ERKs are inactivated by dual-specific phosphatases (DUSPs)

Stable Identifier
R-HSA-203797
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Over 10 dual specificity phosphatases (DUSPs) active on MAP kinases are known. Among them, some possess good ERK docking sites and so are more specific for the ERKS (DUSP 3, 4, 6, 7), others are more specific for p38MAPK (DUSP1 and 10), while others do not seem to discriminate. It is noteworthy that transcription of DUSP genes is induced by growth factor signaling itself, so that these phosphatases provide feedback attenuation of signaling. Moreover, differential activation of DUSPs by different stimuli is thought to contribute to pathway specificity.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of ERK-specific DUSP [nucleoplasm] ERK-specific DUSP [nucleoplasm] protein tyrosine phosphatase activity (0004725)
Orthologous Events