Reactome: A Curated Pathway Database

COPII (Coat Protein 2) Mediated Vesicle Transport (R-HSA-204005)

Species Homo sapiens


COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane.

Locations in the PathwayBrowser
Additional Information
GO Biological Process COPII vesicle coating (0048208)
Cross References
Database Identifier
BioModels Database BIOMD0000000335, BIOMD0000000336
Literature References
pubMedId Title Journal Year
11252894 Three ways to make a vesicle Nat Rev Mol Cell Biol 2000
17316621 Mechanisms of COPII vesicle formation and protein sorting FEBS Lett 2007