COPII-mediated vesicle transport

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane.

Literature References
PubMed ID Title Journal Year
17316621 Mechanisms of COPII vesicle formation and protein sorting FEBS Lett 2007
11252894 Three ways to make a vesicle Nat Rev Mol Cell Biol 2000
Participant Of
Event Information
Go Biological Process
Orthologous Events
Cross References
BioModels Database