Reactome: A Curated Pathway Database

Extracellular KSPG translocates to the lysosome for degradation (R-HSA-2046239)

Species Homo sapiens


As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell or autophagy from inside the cell (Winchester 2005).

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Additional Information
Compartment extracellular region , lysosomal lumen
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Literature References
pubMedId Title Journal Year
15647514 Lysosomal metabolism of glycoproteins Glycobiology 2005