Reactome: A Curated Pathway Database
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Extracellular KSPG translocates to the lysosome for degradation

Stable Identifier
R-HSA-2046239
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell or autophagy from inside the cell (Winchester 2005).

Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins Glycobiology 2005
Participants
Participant Of
Orthologous Events