Reactome: A Curated Pathway Database

Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Species Homo sapiens

Summation

p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. TRKA signalling protects neurons from apoptosis. The molecular mechanisms involved in p75NTR-apoptosis are not well understood. The death signalling requires activation of c-JUN N-terminal Kinase (JNK), as well as transcriptional events. JNK activation appears to involve the receptor interacting proteins TRAF6, NRAGE, and Rac. The transcription events are thought to be regulated by another p75-interacting protein, NRIF. Two other p75-interacting proteins, NADE and Necdin, have been implicated in apoptosis, but their role is less clear.

Locations in the PathwayBrowser
Additional Information
GO Biological Process apoptotic signaling pathway (0097190)
Literature References
pubMedId Title Journal Year
12787561 Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR) Cytokine Growth Factor Rev 2003