Reactome: A Curated Pathway Database

NRIF signals cell death from the nucleus

Stable Identifier
R-HSA-205043
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor.

Literature References
PubMed ID Title Journal Year
15721744 p75NTR--live or let die Curr Opin Neurobiol 2005
Participants
Participant Of
Orthologous Events