Reactome: A Curated Pathway Database

NRIF signals cell death from the nucleus (R-HSA-205043)

Species Homo sapiens


NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor.

Locations in the PathwayBrowser
Additional Information
GO Biological Process positive regulation of apoptotic process (0043065)
Literature References
pubMedId Title Journal Year
15721744 p75NTR--live or let die Curr Opin Neurobiol 2005