Reactome: A Curated Pathway Database
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gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

Stable Identifier
R-HSA-205112
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Neurotrophin or proneurotrophin signalling promotes p75NTR cleavage by gamma-secretase, allowing the release of p75 ICD and NRIF. This mechanism was shown in sympathetic neurons.
Gamma-secretase can be activated in a number of ways, including signalling via p75NTR. The phorbol esther PMA induces p75 cleavage, followed by NRIF nuclear translocation, after 30 min. Neurotrophin binding to p75, instead, triggers the same events only after 12 h.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
peptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] peptidase activity (0008233)
Orthologous Events