Reactome: A Curated Pathway Database
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Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2065355
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
Locations in the PathwayBrowser
Summation

Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino acid residues from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Wei et al. 1991). This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). ACE is secreted ("shed") from membranes of endothelial cells by cleavage in the C-terminal region that removes the membrane anchor.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallodipeptidase activity of ACE(30-1232) [extracellular region] ACE(30-1232) [extracellular region] metallodipeptidase activity (0070573)
Orthologous Events