Reactome: A Curated Pathway Database

Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (R-HSA-2065357)

Species Homo sapiens

Summation

The binding of prorenin to the (pro)renin receptor activates the protease activity of prorenin, which can then hydrolyze angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Prorenin is inactive when not bound to the (pro)renin receptor. Aliskiren, a drug used clinically to treat hypertension, inhibits the cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Prorenin-Prorenin Receptor aspartic-type endopeptidase activity (0004190)
This entry is regulated by
Regulation type Name
NegativeRegulation
Literature References
pubMedId Title Journal Year
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 2002
22193701 Aliskiren displays long-lasting interactions with human renin Naunyn Schmiedebergs Arch Pharmacol 2011
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor Biochem Biophys Res Commun 2003