Reactome: A Curated Pathway Database

Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
R-HSA-2065357
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Prorenin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
Locations in the PathwayBrowser
Summation

The binding of prorenin to the (pro)renin receptor activates the protease activity of prorenin, which can then hydrolyze angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Prorenin is inactive when not bound to the (pro)renin receptor. Aliskiren, a drug used clinically to treat hypertension, inhibits the cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane] Prorenin-Prorenin Receptor [plasma membrane] aspartic-type endopeptidase activity (0004190)
Orthologous Events