Reactome: A Curated Pathway Database

PPM1A dephosphorylates nuclear SMAD2/3 (R-HSA-209055) [Homo sapiens]


In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
p-2S-SMAD2/3:SMAD4:PPM1A protein serine/threonine phosphatase activity (0004722)
Literature References
pubMedId Title Journal Year
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling Cell 2006