Reactome: A Curated Pathway Database
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PPM1A dephosphorylates nuclear SMAD2/3

Stable Identifier
R-HSA-209055
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine phosphatase activity of p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] protein serine/threonine phosphatase activity (0004722)
Orthologous Events