Reactome: A Curated Pathway Database

TRAF6 is auto-ubiquitinated (R-HSA-209566)

Species Homo sapiens


The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Literature References
pubMedId Title Journal Year
15465037 The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination Biochem Biophys Res Commun 2004