Reactome: A Curated Pathway Database

TRAF6 is auto-ubiquitinated

Stable Identifier
R-HSA-209566
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events