Reactome: A Curated Pathway Database

WWTR1:SMAD translocates to the nucleus (R-HSA-2106579) [Homo sapiens]


TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.

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Compartment cytosol , nucleoplasm
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Literature References
pubMedId Title Journal Year
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Nat Cell Biol 2008