Reactome: A Curated Pathway Database
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WWTR1:SMAD translocates to the nucleus

Stable Identifier
R-HSA-2106579
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.

Literature References
Participants
Participant Of
Orthologous Events