Reactome: A Curated Pathway Database

WWTR1:SMAD translocates to the nucleus

Stable Identifier
R-HSA-2106579
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.

Literature References
Participants
Participant Of
Orthologous Events