Reactome: A Curated Pathway Database

Regulation of gene expression in beta cells (R-HSA-210745) [Homo sapiens]


Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expression in turn is controlled by the activities of MAFA, FOXA2, and PAX6, and negatively regulated via AKT (Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004).

Additional Information
GO Biological Process endocrine pancreas development (0031018)
Literature References
pubMedId Title Journal Year
12591178 Transcription factors direct the development and function of pancreatic beta cells Trends Endocrinol Metab 2003
15298336 Transcriptional networks controlling pancreatic development and beta cell function Diabetologia 2004