Reactome: A Curated Pathway Database

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Stable Identifier
R-HSA-210746
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Studies in mouse model systems indicate that the transcription factor neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing pancreas (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). In both mice and humans critical events in this induction process include the neurogenin 3 (NEUROG3)-dependent transcription of PAX4, NEUROD1, NKX2-2, and INSM1.

Literature References
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Participant Of
Orthologous Events