Reactome: A Curated Pathway Database

Regulation of gene expression in early pancreatic precursor cells (R-HSA-210747) [Homo sapiens]


The properties of transcriptional networks early in the differentiation of human pancreatic cells are inferred from the properties of well-studied networks in mouse models. In mice, the first visible sign of pancreatic development is the appearance of pancreatic buds at about embryonic day 9. The cells in these buds are already committed to differentiate into specialized cells of the exocrine and endocrine pancreas. Expression of transcription factors including Hnf1b, Hnf6, and Pdx1, as well as responsiveness to Fgf10 (fibroblast growth factor 10), up-regulates the expression of factors including Ptf1, Onecut3, Lrh1, and Nkx6.1 (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).

Additional Information
Compartment nucleoplasm
GO Biological Process endocrine pancreas development (0031018)
Literature References
pubMedId Title Journal Year
12591178 Transcription factors direct the development and function of pancreatic beta cells Trends Endocrinol Metab 2003
15298336 Transcriptional networks controlling pancreatic development and beta cell function Diabetologia 2004