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PECAM1 interactions

Stable Identifier
R-HSA-210990
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activation and angiogenesis. It has six Ig homology domains within its extracellularly and an ITIM motif within its cytoplasmic region. PECAM-1 mediates cellular interactions by both homophilic and heterophilic interactions. The cytoplasmic domain of PECAM-1 contains tyrosine residues which serves as docking sites for recruitment of cytosolic signaling molecules. Under conditions of platelet activation, PECAM-1 is phosphorylated by Src kinase members. The tyrosine residues 663 and 686 are required for recruitment of the SH2 domain containing PTPs.

Literature References
PubMed ID Title Journal Year
14619965 Platelet endothelial cell adhesion molecule in cell signaling and thrombosis Mol Cell Biochem 2003
12681475 The unfolding tale of PECAM-1 FEBS Lett 2003
Participants
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