Gene Silencing by RNA (R-HSA-211000) [Homo sapiens]


In this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , nuclear envelope , cytosol
GO Biological Process gene silencing by RNA (0031047)
Literature References
pubMedId Title Journal Year
17560368 Argonaute proteins: mediators of RNA silencing Mol Cell 2007
19165215 Biogenesis of small RNAs in animals Nat Rev Mol Cell Biol 2009
19412884 Common themes in siRNA-mediated epigenetic silencing pathways Int J Dev Biol 2009
16510870 Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev 2006
19239886 Origins and Mechanisms of miRNAs and siRNAs Cell 2009
15741316 Perspective: machines for RNAi Genes Dev 2005
21755468 microRNA Biogenesis and Function : An overview Adv Exp Med Biol 2011
25565029 From guide to target: molecular insights into eukaryotic RNA-interference machinery Nat. Struct. Mol. Biol. 2015
Inferred Entries
Orthologous events