Reactome: A Curated Pathway Database

FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein

Stable Identifier
R-HSA-211272
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The PDX1 (IPF1) gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription is positively regulated by the activities of the FOXA2, MAFA, and PAX6 transcription factors. It is negatively regulated by FOXO1A, so events that deplete the nucleoplasmic pool of FOXO1A increase expression of PDX1. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.

Participants
Participant Of
This entity is regulated by:
Inferred From