Reactome: A Curated Pathway Database

FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (R-HSA-211272)

Species Homo sapiens

Summation

The PDX1 (IPF1) gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription is positively regulated by the activities of the FOXA2, MAFA, and PAX6 transcription factors. It is negatively regulated by FOXO1A, so events that deplete the nucleoplasmic pool of FOXO1A increase expression of PDX1. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Output entries
This entry is regulated by
Regulation type Name
NegativeRegulation
PositiveRegulation