Reactome: A Curated Pathway Database

HNF1A-dependent synthesis of the L isoform of PKLR protein (R-HSA-211461)

Species Homo sapiens

Summation

The PKLR gene is transcribed, its mRNA is translated, spliced, and translated to yield the L isoform of PKLR protein. PKLR expression is positively regulated by HNF1A. Mutations in HNF1A are associated with a form of MODY (maturity onset diabetes of the young) (Fanjans et al. 2001) but the molecular details of PKLR expression in intact pancreatic beta cells have not been studied in humans, and are inferred from corresponding ones worked out in the mouse.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , cytosol
Components of this entry
Output entries
This entry is regulated by
Regulation type Name
PositiveRegulation