Reactome: A Curated Pathway Database

CYP4F2, 4F3 20-hydroxylate LTB4 (R-HSA-211873) [Homo sapiens]


Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).

Additional Information
Compartment endoplasmic reticulum membrane , cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Cytochrome P450 (CYP4F2/4F3 based) leukotriene-B4 20-monooxygenase activity (0050051)  
Cross References
Database Identifier
Rhea 22177, 22176, 22179