Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).
|Cytochrome P450 (CYP4F2/4F3 based)||leukotriene-B4 20-monooxygenase activity (0050051)|
|9799565||Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4||Arch Biochem Biophys||1998|
|9539102||Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization||DNA Cell Biol||1998|