Reactome | CYP4B1 12-hydroxylates ARA

CYP4B1 12-hydroxylates ARA

Stable Identifier

R-HSA-211924

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.

Literature References

PubMed ID	Title	Journal	Year
15006160	Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids Mastyugin, V, Ashkar, S, Dunn, MW, Mesentsev, A, Zhang, WX, Laniado-Schwartzman, M	J Ocul Pharmacol Ther	2004