Reactome: A Curated Pathway Database

CYP4B1 12-hydroxylates ARA (R-HSA-211924) [Homo sapiens]


Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.

Additional Information
Compartment smooth endoplasmic reticulum
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Cytochrome P450 (CYP4B1 based) oxygen binding (0019825)