Reactome: A Curated Pathway Database

CYP4F11 16-hydroxylates 3OH-PALM

Stable Identifier
R-HSA-211962
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
monooxygenase activity of Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane] Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane] monooxygenase activity (0004497)
Orthologous Events
Cross References
Rhea