Reactome: A Curated Pathway Database

CYP4F11 16-hydroxylates 3OH-PALM (R-HSA-211962) [Homo sapiens]


Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).

Additional Information
Compartment smooth endoplasmic reticulum
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Cytochrome P450 (CYP4F11 based) monooxygenase activity (0004497)  
Cross References
Database Identifier
Rhea 39732, 39731
Literature References
pubMedId Title Journal Year
18065749 Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11 J Lipid Res 2008