Reactome: A Curated Pathway Database

Xenobiotics (R-HSA-211981)

Species Homo sapiens

Summation

Of the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
15102545 57 varieties: the human cytochromes P450 Pharmacogenomics 2004
16584116 Cytochrome P450s and other enzymes in drug metabolism and toxicity AAPS J 2006
12369887 The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans Curr Drug Metab 2002