Of the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.
|Compartment||endoplasmic reticulum membrane , endoplasmic reticulum lumen|
|GO Biological Process||xenobiotic metabolic process (0006805)|
|15102545||57 varieties: the human cytochromes P450||Pharmacogenomics||2004|
|16584116||Cytochrome P450s and other enzymes in drug metabolism and toxicity||AAPS J||2006|
|12369887||The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans||Curr Drug Metab||2002|