Sterols are 12-hydroxylated by CYP8B1

Stable Identifier
R-HSA-211994
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Sterols are 12-hydroxylated by CYP8B1
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Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid (Gafvels et al. 1999).
Literature References
PubMed ID Title Journal Year
10051404 Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

Gafvels, M, Bjorkhem, I, Jansson, M, Raudsepp, T, Chowdhary, BP, Andersson, U, Persson, B, Eggertsen, G, Olin, M

Genomics 1999
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
sterol metabolic process (0016125)
Orthologous Events
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
Sterols are 12-hydroxylated by CYP8B1 (Mus musculus)
Sterols are 12-hydroxylated by CYP8B1 (Rattus norvegicus)
Sterols are 12-hydroxylated by CYP8B1 (Sus scrofa)
Sterols are 12-hydroxylated by CYP8B1 (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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