Reactome: A Curated Pathway Database

EGFR interacts with phospholipase C-gamma (R-HSA-212718)

Species Homo sapiens


Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.

Locations in the PathwayBrowser
Additional Information
GO Biological Process signal transduction (0007165)
Literature References
pubMedId Title Journal Year
1501243 Epidermal growth factor receptor: elements of intracellular communication J Membr Biol 1992