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EGFR interacts with phospholipase C-gamma
Stable Identifier
R-HSA-212718
DOI
10.3180/REACT_12478.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR interacts with phospholipase C-gamma (Homo sapiens)
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Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.
Literature References
PubMed ID
Title
Journal
Year
1501243
Epidermal growth factor receptor: elements of intracellular communication
Hernández-Sotomayor, SM
,
Carpenter, G
J Membr Biol
1992
Participants
Events
Phospholipase C-gamma1 binds to the activated EGF receptor
(Homo sapiens)
EGFR activates PLC-gamma1 by phosphorylation
(Homo sapiens)
Active PLC-gamma1 dissociates from EGFR
(Homo sapiens)
Participates
as an event of
Signaling by EGFR (Homo sapiens)
Event Information
Go Biological Process
signal transduction (0007165)
Orthologous Events
EGFR interacts with phospholipase C-gamma (Bos taurus)
EGFR interacts with phospholipase C-gamma (Canis familiaris)
EGFR interacts with phospholipase C-gamma (Danio rerio)
EGFR interacts with phospholipase C-gamma (Drosophila melanogaster)
EGFR interacts with phospholipase C-gamma (Gallus gallus)
EGFR interacts with phospholipase C-gamma (Mus musculus)
EGFR interacts with phospholipase C-gamma (Rattus norvegicus)
EGFR interacts with phospholipase C-gamma (Sus scrofa)
EGFR interacts with phospholipase C-gamma (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000399
,
BIOMD0000000883
,
BIOMD0000000656
,
BIOMD0000000655
,
BIOMD0000000648
,
BIOMD0000000652
,
BIOMD0000000019
,
BIOMD0000000654
,
BIOMD0000000175
,
BIOMD0000000255
,
BIOMD0000000477
,
BIOMD0000000595
,
BIOMD0000000223
,
BIOMD0000000653
Authored
Jassal, B (2008-02-13)
Reviewed
Heldin, CH (2008-02-12)
Created
Jassal, B (2008-02-13)
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