Reactome will be unavailable due to host maintenance from Friday, April 27 at 6pm to Sunday, April 29 at 11:55pm.

During the outage, you may wish to use our mirror site at reactome.ncpsb.org.

EGFR interacts with phospholipase C-gamma

Stable Identifier
R-HSA-212718
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.

Literature References
PubMed ID Title Journal Year
1501243 Epidermal growth factor receptor: elements of intracellular communication J Membr Biol 1992
Participants
Participant Of
Event Information
Go Biological Process