Reactome: A Curated Pathway Database

Generation of CLIP from lip10

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The lip10 fragments bound in the nonameric complex are processed leaving only the CLIP fragment (81-105) bound to the MHC II peptide binding groove. Three cysteine proteases have been shown to be capable of digesting lip10, each with a different expression pattern among different APC. Cathepsin (Cat) S digests Ii in B cells and dendritic cells, thymic epithelial cells use Cat L and Cat L, while Cat S and F are active in macrophages (Villadangos, 2001; Bryant et al, 2002). Cat S appears to be the major enzyme involved as demonstrated by the use of specific inhibitors and of knockout experiments (Stumptner-Cuvelette et al. 2002). Following lip10 digestion, the MHC-like molecule HLA-DM induces the exchange of CLIP fragment for a highly diverse array of antigens (Denzin & Cresswell. 1995).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen] Cathepsin [lysosomal lumen] cysteine-type endopeptidase activity (0004197)
Orthologous Events