Reactome: A Curated Pathway Database

Transport of MHC II:Ii complex to plasma membrane

Stable Identifier
R-HSA-2130378
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
transport vesicle membrane, trans-Golgi network membrane
Locations in the PathwayBrowser
Summation

The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane.

Literature References
PubMed ID Title Journal Year
10540230 Cell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell lines Immunology 1999
8397411 Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization Proc Natl Acad Sci U S A 1993
16824007 The formation of TGN-to-plasma-membrane transport carriers Annu Rev Cell Dev Biol 2006
14731593 Targeting of membrane proteins to endosomes and lysosomes Trends Cell Biol 1994
Participants
input
output
Participant Of
hasEvent
Orthologous Events
 
Follow Reactome