Reactome: A Curated Pathway Database

Cleavage of lip22 to lip10

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The cleavage of lip22 occurs in residues 115-125, closer to the C-terminus than CLIP (residues 81-105). The resulting lip10 fragment is approximately 100 residues long and extends just through the C-terminus of the Ii CLIP. The proteases responsible for generating lip10 in vivo are not determined. Cysteine proteases like cathepsin S (CatS) are capable of degrading lip22 to lip10 (Bania et al. 2003) but in the presence of LHVS, an inhibitor of CatS, lip22 degradation is still observed, suggesting that other proteases are involved (Villadangos et al. 1997), possibly aspartic proteinases such as cathepsins D and E (Kageyama et al. 1996). The degradation of lip22 may depend on cell type (Bania et al. 2003). The lip22 and lip10 intermediate forms are still maintained as a nonameric complex due to the existence of the last trimerisation domain in the transmembrane region.

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen] Cathepsin [lysosomal lumen] cysteine-type endopeptidase activity (0004197)
Orthologous Events